Firefighters were called to an abandoned house northeast of downtown Wednesday evening by a driver who saw smoke coming from the address.
When they arrived at 119 Avenue and 78 Street shortly before 8:20 p.m., crews found flames at the boarded-up building.
In total, five units helped in the firefight.
The blaze was brought under control by 1:20 a.m. and declared out before 11 a.m.
No injuries were reported.
A spokesperson with Edmonton Fire Rescue Services said the cause of the fire is under investigation, and confirmed firefighters have been called to the location three other times since September.